Lipids are oxidized. Oxidation of fatty acids alters the properties of cell membranes
Among the products of this process are malondialdehyde and 4-hydroxynonenal.
Biological oxidation reactions are accompanied by the formation of free radicals, particles with an unpaired electron in the outer orbit. This is responsible for the high chemical activity of these radicals. For example, they react with unsaturated fatty acids in membranes, disrupting their structure. Antioxidants prevent free radical oxidation.
Through the stage of peroxide derivatives of unsaturated fatty acids, the biosynthesis of prostaglandins and leukotrienes is carried out, and thromboxanes, which have a powerful effect on the adhesive-aggregation properties of blood cells and microcirculation, are themselves hydroperoxides. The formation of cholesterol hydroperoxides is one of the links in the synthesis of some steroid hormones, in particular, progesterone.
Literature
- Vladimirov Yu.A., Archakov A.I. Lipid peroxidation in biological membranes. - Moscow: Nauka, 1972 .-- 252 p.
- Baraboy V.A., Orel V.E., Karnaukh I.M. Peroxidation and radiation. - K .: Naukova Dumka, 1991.
- V. V. Kovshevny - free radical oxidation
Notes
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